alpha-Bromo-o-fluorotoluene → Tert-butyl 4-(2-fluorobenzyl)piperazine-1-carboxylate

HRID 1804628Notes

Reaction equation

HRID 1804628 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[F:9].[N:10]1([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[F:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][N:13]1[CH2:12][CH2:11][N:10]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 67968alpha-Bromo-o-fluorotolueneHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 67971976Tert-butyl 4-(2-fluorobenzyl)piperazine-1-carboxylate

Procedure

Prepared from 1-(bromomethyl)-2-fluorobenzene and tert-butyl 1-piperazine-carboxylate using the procedure described in Step A of Intermediate 113. LC/MS: m/z (ES) 295.0 (MH)+.

Sources & evidence

ORD record
ord-e9e366af236546378a2b566a16c7e94d
Source dataset
uspto-grants-2013_01
Patent number
US08354403B2

Reaction notes

Loading…