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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804628Generated: October 26, 2026

alpha-Bromo-o-fluorotoluene → Tert-butyl 4-(2-fluorobenzyl)piperazine-1-carboxylate

https://huagongshe.com/reaction/1804628

Reaction equation

Participants

RoleNameHCIDCharge
Reactantalpha-Bromo-o-fluorotolueneHCID 67968—
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
ProductTert-butyl 4-(2-fluorobenzyl)piperazine-1-carboxylateHCID 67971976—

Reaction Steps

Prepared from 1-(bromomethyl)-2-fluorobenzene and tert-butyl 1-piperazine-carboxylate using the procedure described in Step A of Intermediate 113. LC/MS: m/z (ES) 295.0 (MH)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354403B2
Source datasetuspto-grants-2013_01
ORD IDord-e9e366af236546378a2b566a16c7e94d
Source noteuspto-grants-2013_01