反应详情

温度

10 °C

To a suspension of 158 g of 1-(2,2-dimethoxyethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one in 1.26 L of 2-butanone, 79 mL of 12 mol/L hydrochloric acid was added at room temperature, and the mixture was refluxed for 3 hours. After cooling the reaction mixture to 10° C., the solid product was obtained by filtration and washed with 2-butanone to give 152 g of (7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)acetaldehyde hydrochloride monohydrate as a light yellow solid.

1. additionwas added at room temperature
2. temperaturethe mixture was refluxed for 3 hours
3. customthe solid product was obtained by filtration
4. washwashed with 2-butanone