1H-pyrrolo(2,3-b)pyridin-5-amine → HCID 44194001, compound

HRID 1804738Notes

Reaction equation

HRID 1804738 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=1)[C:6]([C:19](O)=[O:20])=[CH:5]2.[NH2:22][C:23]1[CH:24]=[C:25]2[CH:31]=[CH:30][NH:29][C:26]2=[N:27][CH:28]=1>>[NH:29]1[C:26]2=[N:27][CH:28]=[C:23]([NH:22][C:19]([C:6]3[N:7]([CH2:11][C:12]4[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=4)[C:8]4[C:4]([CH:5]=3)=[CH:3][C:2]([F:1])=[CH:10][CH:9]=4)=[O:20])[CH:24]=[C:25]2[CH:31]=[CH:30]1

Participants

3

Reactant 2

HCID 117151871H-pyrrolo(2,3-b)pyridin-5-amineHCID 574315135-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid

Product 1

HCID 44194001HCID 44194001, compoundYield 78.7%

Procedure

The process is performed according to a method similar to that described in Example 1.3 starting with 0.4 g (1.39 mmol) of 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid prepared in step 1.1 and 0.22 g (1.67 mmol) of 5-amino-1H-pyrrolo[2,3-b]pyridine (Synthesis 2005, 15, 2503). 0.44 g of the expected product is thus isolated in the form of a white solid.

Sources & evidence

ORD record
ord-4e23bac06cd6413faed62fd2231c42d1
Source dataset
uspto-grants-2013_01
Patent number
US08354425B2

Reaction notes

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