1H-Pyrrolo[3,2-b]pyridin-6-amine → HCID 44194003, compound

HRID 1804739Notes

Reaction equation

HRID 1804739 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=1)[C:6]([C:19]([OH:21])=O)=[CH:5]2.[NH2:22][C:23]1[CH:24]=[C:25]2[NH:31][CH:30]=[CH:29][C:26]2=[N:27][CH:28]=1>>[NH:31]1[C:25]2[C:26](=[N:27][CH:28]=[C:23]([NH:22][C:19]([C:6]3[N:7]([CH2:11][C:12]4[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=4)[C:8]4[C:4]([CH:5]=3)=[CH:3][C:2]([F:1])=[CH:10][CH:9]=4)=[O:21])[CH:24]=2)[CH:29]=[CH:30]1

Participants

3

Reactant 2

HCID 242292681H-Pyrrolo[3,2-b]pyridin-6-amineHCID 574315135-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid

Product 1

HCID 44194003HCID 44194003, compoundYield 39.3%

Procedure

The process is performed according to a method similar to that of Example 1.3 starting with 0.4 g (1.39 mmol) of 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid prepared in step 1.1 and 0.22 g (1.67 mmol) of 6-amino-1H-pyrrolo[3,2-b]pyridine (Adesis). 0.22 g of the expected product is thus isolated in the form of a white solid.

Sources & evidence

ORD record
ord-2051a697c9c043c181a02c024548a03e
Source dataset
uspto-grants-2013_01
Patent number
US08354425B2

Reaction notes

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