反应详情

温度

27.5 °C

N-Ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide (18 gm) and ethanol (180 ml) were stirred at 25-30° C. for 15 minutes followed by the addition of 40% sodium hydroxide solution (5.6 ml) at 25-30° C. in 10 minutes. The resulted clear solution was stirred at 25-30° C. for 20 hours. The precipitated white colored solid was filtered, washed with ethanol (20 ml) and then dried at 55-60° C. to a constant weight to yield 13 gm of laquinimod sodium in crystalline Form A2.

1. filtrationThe precipitated white colored solid was filtered
2. washwashed with ethanol (20 ml)
3. customdried at 55-60° C. to a constant weight