Sodium Hydroxide → Laquinimod Sodium

Participants

Reaction Conditions

Reaction Steps

N-Ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide (18 gm) and ethanol (180 ml) were stirred at 25-30° C. for 15 minutes followed by the addition of 40% sodium hydroxide solution (5.6 ml) at 25-30° C. in 10 minutes. The resulted clear solution was stirred at 25-30° C. for 20 hours. The precipitated white colored solid was filtered, washed with ethanol (20 ml) and then dried at 55-60° C. to a constant weight to yield 13 gm of laquinimod sodium in crystalline Form A2.

Provenance & Evidence