HuagongsheHuagongshe Chemistry Print Report · For research reference only
(-)-Dibenzoyltartrate → 2,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester (-)-dibenzoyltartrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (-)-Dibenzoyltartrate | HCID 21978704 | — |
| Reactant | 2,2-Dimethyl-propionic acid (3RS,4RS)-3-methyl-piperidin-4-yl ester | HCID 66842134 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester (-)-dibenzoyltartrate | HCID 131730155 | — |
Reaction Steps
2,2-Dimethyl-propionic acid (3RS,4RS)-3-methyl-piperidin-4-yl ester (5) (9.6 g, 48 mmol) is dissolved in 50 ml of ethyl acetate. A solution of (−)-dibenzoyltartrate (8.6 g, 24 mmol) in ethyl acetate is added drop wise. The precipitate is filtrated off and washed with cold ethyl acetate to yield colourless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354431B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-5dd345f6fc7e4ea281f841b92d6979a7 |
| Source note | uspto-grants-2013_01 |