HRID1804761

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C([O-])C(O)(C(=O)c1ccccc1)C(O)(C(=O)[O-])C(=O)c1ccccc1

HCID21978704

未命名化合物

HCID66842134

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1CNCC[C@@H]1OC(=O)C(C)(C)C.O=C(O)C(O)(C(=O)c1ccccc1)C(O)(C(=O)O)C(=O)c1ccccc1

HCID131730155

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

2,2-Dimethyl-propionic acid (3RS,4RS)-3-methyl-piperidin-4-yl ester (5) (9.6 g, 48 mmol) is dissolved in 50 ml of ethyl acetate. A solution of (−)-dibenzoyltartrate (8.6 g, 24 mmol) in ethyl acetate is added drop wise. The precipitate is filtrated off and washed with cold ethyl acetate to yield colourless crystals.

WORKUP

后处理

filtrationThe precipitate is filtrated off
washwashed with cold ethyl acetate
customto yield colourless crystals

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5dd345f6fc7e4ea281f841b92d6979a7
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08354431B2
来源说明: uspto-grants-2013_01

反应 SMILES

[CH3:1][CH:2]1[CH:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1.[C:15]([C:23]([C:38]([O-:40])=[O:39])([OH:37])[C:24]([C:29](=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:28])[C:25]([O-:27])=[O:26])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(OCC)(=O)C>[C:29]([C:24]([C:25]([OH:27])=[O:26])([OH:28])[C:23]([C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([OH:37])[C:38]([OH:40])=[O:39])(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[CH3:1][C@@H:2]1[C@@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1