反应详情

温度

0 °C

Bromocyclohexene (35.9 ml, 310.5 mmol) is dissolved in 1 l of DMF, cooled down to 0° C. and after addition of benzenesulfinic acid sodium salt (86.6 g, 527.8 mmol) the mixture is stirred for 17 h at room temperature. Then the mixture is evaporated under high vacuum. The residue is diluted with ether, washed with water, dried over Na2SO4 and evaporated under reduced pressure. The crude product is purified by Flash-chromatography (ethyl acetate/hexanes (1:9), 1 kg silicagel).

1. customThen the mixture is evaporated under high vacuum
2. additionThe residue is diluted with ether
3. washwashed with water
4. dry with materialdried over Na2SO4
5. customevaporated under reduced pressure
6. customThe crude product is purified by Flash-chromatography (ethyl acetate/hexanes (1:9), 1 kg silicagel)