反应详情

温度

0 °C

3-Methoxy-phenol (43.4 ml, 400 mmol) is dissolved in acetone (800 ml) and after addition of chloro-acetic acid ethyl ester (42.6 ml, 400 mmol) and K2CO3 (111 g, 800 mmol) the mixture is refluxed for 22 h. After cooling down to 0° C., the mixture is filtrated and the filtrate is evaporated under reduced pressure. The residue is diluted in ethyl acetate, cooled to 0° C. and washed with aqueous NaOH solution. The organic layer is dried over sodium sulfate and evaporated under reduced pressure.

1. temperatureis refluxed for 22 h
2. filtrationthe mixture is filtrated
3. customthe filtrate is evaporated under reduced pressure
4. additionThe residue is diluted in ethyl acetate
5. temperaturecooled to 0° C.
6. washwashed with aqueous NaOH solution
7. dry with materialThe organic layer is dried over sodium sulfate
8. customevaporated under reduced pressure