反应详情

温度

0 °C

1M LiAlH4-solution in THF (47.6 ml, 47.6 mmol) is diluted with 200 ml of THF and cooled to 0° C. 6-Ethoxy-benzofuran-3-carboxylic acid ethyl ester (27a) (5.6 g, 23.8 mmol) is dissolved in 100 ml of THF and added drop wise within 30 min. After completed addition the mixture is allowed to stir at 0° C. for 2 h. Then the reaction mixture is cooled to −15° C. and 10 ml of a 1M NaOH solution is added very slowly. Then the mixture is filtrated over celite, washed with THF and evaporated under reduced pressure.

1. additionadded drop wise within 30 min
2. additionaddition the mixture
3. temperatureThen the reaction mixture is cooled to −15° C.
4. filtrationThen the mixture is filtrated over celite
5. washwashed with THF
6. customevaporated under reduced pressure