Bromomethylcyclopropane → HCID 59152656, compound

HRID 1804793Notes

Reaction equation

HRID 1804793 reaction equation
[CH2:1]([O:3][C:4]1[CH:26]=[CH:25][C:7]2[C:8]([CH2:11][O:12][C:13]3[CH:21]=[CH:20][CH:19]=[C:18]4[C:14]=3[CH:15]=[C:16]([C:22]([OH:24])=[O:23])[NH:17]4)=[CH:9][O:10][C:6]=2[CH:5]=1)[CH3:2].[CH2:27](OC(C1C2C=CC(O)=CC=2OC=1)=O)[CH3:28].BrCC1CC1>>[CH:2]1([CH2:1][O:3][C:4]2[CH:26]=[CH:25][C:7]3[C:8]([CH2:11][O:12][C:13]4[CH:21]=[CH:20][CH:19]=[C:18]5[C:14]=4[CH:15]=[C:16]([C:22]([OH:24])=[O:23])[NH:17]5)=[CH:9][O:10][C:6]=3[CH:5]=2)[CH2:28][CH2:27]1

Participants

4

Reactant 3

HCID 81503BromomethylcyclopropaneHCID 59152646HCID 59152646, compoundHCID 59152664HCID 59152664, compound

Product 1

HCID 59152656HCID 59152656, compound

Procedure

4-(6-cyclopropylmethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (30b) is synthesized analogous to 30a from 6-Hydroxy-benzofuran-3-carboxylic acid ethyl ester (26) and bromomethyl cyclopropane.

Sources & evidence

ORD record
ord-4e3b2d8d1cc243abae8cf8bbef9230f0
Source dataset
uspto-grants-2013_01
Patent number
US08354431B2

Reaction notes

Loading…