反应详情

温度

130 °C

A 2-chloropyrimidine was dissolved in isopropyl alcohol to which was added diisopropylamine. The reaction was heated in a sealed tube for ten days at 130° C. The cooled reaction mixture was concentrated, and the product purified via silica gel column chromatography to yield the 2-isopropoxypyrimidine.

1. customThe cooled reaction mixture
2. concentrationwas concentrated
3. customthe product purified via silica gel column chromatography