Isoamyl Nitrite → HCID 86657091, compound

HRID 1804824Notes

Reaction equation

HRID 1804824 reaction equation
[N:1](OCCC(C)C)=O.[NH2:9][C:10]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:11]=1[C:17](=[O:38])[CH:18]=[P:19]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>Cl>[F:16][C:15]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:10]=1[N:9]=[N:1][C:18](=[P:19]([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[C:17]2=[O:38]

Participants

4

Reactant 2

HCID 8053Isoamyl NitriteHCID 86657092HCID 86657092, compound

Product 1

HCID 86657091HCID 86657091, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Isoamyl nitrite (1.9 eq) was added to a stirred solution of D2 in HCl (0.5 M solution in MeOH) at 0° C. After the consumption of the starting material (15-30 min), the solution was allowed to warm to RT and was made alkaline (pH=9) by addition of 10% NaOH. The resulting precipitate was collected by filtration affording the title compound as a white solid.

Workup

  1. customAfter the consumption of the starting material (15-30 min)
  2. additionby addition of 10% NaOH
  3. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-b66ef063de074d44b38c27ce08aaf660
Source dataset
uspto-grants-2013_01
Patent number
US08354413B2

Reaction notes

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