Methyl 5-(bromomethyl)-2-fluorobenzoate → HCID 86657093, compound

HRID 1804825Notes

Reaction equation

HRID 1804825 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[N:9][C:8](=[P:12]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]2=[O:31].[Br:32][CH2:33][C:34]1[CH:35]=[CH:36][C:37]([F:44])=[C:38]([CH:43]=1)[C:39]([O:41][CH3:42])=[O:40]>C(#N)C>[Br-:32].[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]([CH2:33][C:34]1[CH:35]=[CH:36][C:37]([F:44])=[C:38]([C:39]([O:41][CH3:42])=[O:40])[CH:43]=1)[N:9]=[C:8]([P+:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:7]2=[O:31]

Participants

4

Reactant 2

HCID 22645461Methyl 5-(bromomethyl)-2-fluorobenzoateHCID 86657091HCID 86657091, compound

Product 1

HCID 86657093HCID 86657093, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of D3 and methyl 5-(bromomethyl)-2-fluorobenzoate (prepared as described in US 2007/0021427) (1 eq) in ACN (0.1 M) was heated to reflux for 1 h 30 min. After cooling down, evaporation of the solvent under reduced pressure afforded the title compound as yellow foam.

Workup

  1. temperatureto reflux for 1 h 30 min
  2. temperatureAfter cooling down
  3. customevaporation of the solvent under reduced pressure

Sources & evidence

ORD record
ord-2cb330486b0a489ab9d20928d99d3dc3
Source dataset
uspto-grants-2013_01
Patent number
US08354413B2

Reaction notes

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