反应详情

温度

60 °C

1-(5-fluoropyridin-2-yl)cyclopropanecarbonitrile (880 mg) was dissolved in ethanol (10 ml) before slow, dropwise addition of 96% sulfuric acid (10 ml). The reaction mixture was allowed to stir at 60° C. for 24 hr. Upon cooling, NaHCO3 was added until pH 8 and then the solution extracted three times with ethyl acetate, the organics were washed with brine and dried over Na2SO4 before concentration in vacuo.

1. temperatureUpon cooling
2. extractionthe solution extracted three times with ethyl acetate
3. washthe organics were washed with brine
4. dry with materialdried over Na2SO4 before concentration in vacuo