Potassium Carbonate → methyl 2-chloro-6-methoxypyrimidine-4-carboxylate

HRID 1805247Notes

Reaction equation

HRID 1805247 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4](Cl)[N:3]=1.[C:13](=O)([O-])[O-:14].[K+].[K+]>CO>[CH3:11][O:10][C:8]([C:6]1[CH:5]=[C:4]([O:14][CH3:13])[N:3]=[C:2]([Cl:1])[N:7]=1)=[O:9]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 239689Methyl 2,4-dichloropyrimidine-6-carboxylate

Product 1

HCID 312614methyl 2-chloro-6-methoxypyrimidine-4-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 2,6-dichloropyrimidine-4-carboxylate (1 g) was combined with MeOH (20 ml) to give a light yellow solution. Potassium carbonate (668 mg) was added and the reaction mixture was stirred at RT for 6 h. The solvent was concentrated in vacuo and the residue was stirred in Et2O. The suspension was filtered and the filtrate was concentrated in vacuo to afford title compound as a white solid. MS (ISP): 203.3 ([M+H]+)

Workup

  1. customto give a light yellow solution
  2. concentrationThe solvent was concentrated in vacuo
  3. stirringthe residue was stirred in Et2O
  4. filtrationThe suspension was filtered
  5. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-0aead03d699b49fdbf0fdb368ee886b7
Source dataset
uspto-grants-2013_01
Patent number
US08354441B2

Reaction notes

Loading…