HCID 67151586, compound → HCID 67151667, compound

HRID 1805248Notes

Reaction equation

HRID 1805248 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][CH3:12])[N:8]=[C:7]([CH:13]=[CH2:14])[N:6]=1)=[O:4]>[Pd].CO>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][CH3:12])[N:8]=[C:7]([CH2:13][CH3:14])[N:6]=1)=[O:4]

Participants

4

Reactant 1

HCID 67151586HCID 67151586, compound

Product 1

HCID 67151667HCID 67151667, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6-Methoxy-2-vinyl-pyrimidine-4-carboxylic acid methyl ester (130 mg) was combined with MeOH (5 ml) to give a light yellow solution. Pd/C 10% (13 mg) was added and the reaction mixture was hydrogenated with a balloon at RT for 4 hours. The reaction mixture was filtered and the filtrate was concentrated in vacuo to give title compound as an off white solid. MS (ISP) 197.1 ([M+H]

Workup

  1. customto give a light yellow solution
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-4a5322c5edf244cea92956905fbaed77
Source dataset
uspto-grants-2013_01
Patent number
US08354441B2

Reaction notes

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