4-Chlorobenzaldehyde → 3-(4-Chlorobenzylidene)indolin-2-one

Participants

Reaction Steps

Oxindole (0.13 g, 1 mmol), 4-chlorobenzaldehyde (0.17 g, 1.2 mmol) were mixed in alcohol; then pyrrolidine (0.17 ml, 2 mmol) was added. The mixture was refluxed for 3 hours. The formed precipitates was collected by filtration and washed with alcohol twice to give the title compound as yellow powder (0.24 g, 92%). LC/MS m/e calcd. for C15H10ClNO 255, observed (M+H)+: 256.1.

Provenance & Evidence