反应详情

温度

75 °C

To a mixture of 2-amino-3-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one (10 g, 0.04 mol) in MeOH (334 mL) was added 10% Pd/C (2 g), ammonium formate (13.2 g, 0.21 mmol) and heated at 75° C. for 4 h. After completion of the reaction, the reaction mixture was cooled and filtered through a pad of Celite with hot 1:1 DMF/MeOH. The filtrate was concentrated in vacuo to provide the product as an off-white solid (6.2 g, 99%).

1. customAfter completion of the reaction
2. temperaturethe reaction mixture was cooled
3. filtrationfiltered through a pad of Celite with hot 1:1 DMF/MeOH
4. concentrationThe filtrate was concentrated in vacuo