Hydrochloric Acid → 5-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide hydrochloride

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Reaction Steps

1,1-Dimethylethyl-4-[7-(aminocarbonyl)-5-bromo-1H-indol-3-yl]-1-piperidinecarboxylate (which may be prepared according to WO2005067923A1, 74 g) was dissolved/suspended in methanol (300 mL) and to this was added 4N HCl in dioxane (200 mL). The reaction mixture was stirred for 2 hours. Diethyl ether (400 mL) was added and the solid was collected by filtration. This was washed with diethyl ether (300 mL) and dried in vacuo to give the title compound (66.53 g) as pale yellow solid.

Provenance & Evidence