Hydrochloric Acid → 5-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide hydrochloride

HRID 1805887Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1805887
CC([CH:5]1[CH2:10][CH:9]([C:11]2[C:19]3[C:14](=[C:15]([C:21]([NH2:23])=[O:22])[CH:16]=[C:17]([Br:20])[CH:18]=3)[NH:13][CH:12]=2)[CH2:8][CH2:7][N:6]1C([O-])=O)(C)C.[ClH:27].C(OCC)C>CO.O1CCOCC1>[ClH:27].[Br:20][C:17]1[CH:18]=[C:19]2[C:14](=[C:15]([C:21]([NH2:23])=[O:22])[CH:16]=1)[NH:13][CH:12]=[C:11]2[CH:9]1[CH2:10][CH2:5][NH:6][CH2:7][CH2:8]1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 866161311,1-Dimethylethyl-4-[7-(aminocarbonyl)-5-bromo-1H-indol-3-yl]-1-piperidinecarboxylate

Produkt 1

HCID 667232845-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

1,1-Dimethylethyl-4-[7-(aminocarbonyl)-5-bromo-1H-indol-3-yl]-1-piperidinecarboxylate (which may be prepared according to WO2005067923A1, 74 g) was dissolved/suspended in methanol (300 mL) and to this was added 4N HCl in dioxane (200 mL). The reaction mixture was stirred for 2 hours. Diethyl ether (400 mL) was added and the solid was collected by filtration. This was washed with diethyl ether (300 mL) and dried in vacuo to give the title compound (66.53 g) as pale yellow solid.

Aufarbeitung

  1. filtrationthe solid was collected by filtration
  2. washThis was washed with diethyl ether (300 mL)
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-13163615f3a745f09e50441a0cbec948
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354539B2

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