Hydrochloric Acid → HCID 45255992, compound

HRID 1805927Notes

Reaction equation

HRID 1805927 reaction equation
[C:1](=[O:62])([O:51][C:52]1[C:57]([O:58][CH3:59])=[CH:56][CH:55]=[CH:54][C:53]=1[O:60][CH3:61])[O:2][C@H:3]([C:37]1[CH:42]=[C:41]([C:43]([F:46])([F:45])[F:44])[CH:40]=[C:39]([C:47]([F:50])([F:49])[F:48])[CH:38]=1)[C@@H:4]([N:6](C(OC(C)(C)C)=O)[CH2:7][C:8]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][C:9]=1[C:18]1[CH:23]=[C:22]([CH:24]([CH3:26])[CH3:25])[C:21]([F:27])=[CH:20][C:19]=1[O:28][CH3:29])[CH3:5].[ClH:63]>>[Cl-:63].[F:49][C:47]([F:48])([F:50])[C:39]1[CH:38]=[C:37]([C@@H:3]([O:2][C:1]([O:51][C:52]2[C:57]([O:58][CH3:59])=[CH:56][CH:55]=[CH:54][C:53]=2[O:60][CH3:61])=[O:62])[C@@H:4]([NH2+:6][CH2:7][C:8]2[CH:13]=[C:12]([C:14]([F:16])([F:17])[F:15])[CH:11]=[CH:10][C:9]=2[C:18]2[CH:23]=[C:22]([CH:24]([CH3:25])[CH3:26])[C:21]([F:27])=[CH:20][C:19]=2[O:28][CH3:29])[CH3:5])[CH:42]=[C:41]([C:43]([F:44])([F:45])[F:46])[CH:40]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86657396HCID 86657396, compound

Product 1

HCID 45255992HCID 45255992, compound

Procedure

A solution of (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-((tert-butoxycarbonyl){[4′-fluoro-5′-isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)propyl 2,6-dimethoxyphenyl carbonate (125.7 mg, 0.141 mmol) in HCl saturated EtOAc (4 mL) was stirred at 25° C. for 5 h. The reaction mixture was concentrated in vacuo to afford (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-1-{[(2,6-dimethoxyphenoxy)carbonyl]oxy}-N-{[4′-fluoro-5′-isopropyl-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}propan-2-aminium chloride, as a colorless oil/glass. LCMS calc.=792.2; found=792.2 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-4a991811da84450d802e5ec0bebee62c
Source dataset
uspto-grants-2013_01
Patent number
US08354454B2

Reaction notes

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