HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → HCID 178518411, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)benzoic acid | HCID 57600107 | — |
| Product | HCID 178518411 | HCID 178518411 | 75% |
Reaction Steps
10.0 g (64.0 mmol) of methylester 3-aminothiophene-2-carboxylate (I) and 19.0 g (31.60 mmol) of urea are mixed and melted for 2 hours at 200° C. After cooling, the reaction mixture is dissolved in 1 molar sodium hydroxide solution and decolorized with activated charcoal. It is filtered and the filtrate is cooled and acidified with 4M hydrochloric acid. The precipitate formed is suction filtered and dried. 8.03 g of product II (75%) is obtained as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354531B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-af2a06948cb2485f8b3359544a4488d2 |
| Source note | uspto-grants-2013_01 |