Methane → HCID 178518411, compound

HRID 1805997Notes

Reaction equation

HRID 1805997 reaction equation
ClC1N=[C:4](NC2C=C(C=CC=2)C(O)=O)[C:5]2[S:10][CH2:9][CH2:8][C:6]=2N=1.[NH2:21][C:22]([NH2:24])=[O:23].C.[OH-:26].[Na+]>>[N:21]1[C:6]2[CH:8]=[CH:9][S:10][C:5]=2[C:4]([OH:26])=[N:24][C:22]=1[OH:23]

Participants

5

Reactant 4

HCID 297MethaneHCID 1176UreaHCID 14798Sodium HydroxideHCID 576001073-(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)benzoic acid

Product 1

HCID 178518411HCID 178518411, compoundYield 75%

Procedure

10.0 g (64.0 mmol) of methylester 3-aminothiophene-2-carboxylate (I) and 19.0 g (31.60 mmol) of urea are mixed and melted for 2 hours at 200° C. After cooling, the reaction mixture is dissolved in 1 molar sodium hydroxide solution and decolorized with activated charcoal. It is filtered and the filtrate is cooled and acidified with 4M hydrochloric acid. The precipitate formed is suction filtered and dried. 8.03 g of product II (75%) is obtained as a powder.

Workup

  1. temperatureAfter cooling
  2. filtrationIt is filtered
  3. temperaturethe filtrate is cooled
  4. customThe precipitate formed
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-af2a06948cb2485f8b3359544a4488d2
Source dataset
uspto-grants-2013_01
Patent number
US08354531B2

Reaction notes

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