Dichloromethane → 8-(Piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

HRID 180621Notes

Reaction equation

HRID 180621 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][c:17]3[cH:18][c:19]4[n:20]([c:21]3[cH:22][cH:23]2)[CH2:24][CH2:25][NH:26][C:27]4=[O:28])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:36][CH2:37][Cl:38].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][c:17]3[cH:18][c:19]4[n:20]([c:21]3[cH:22][cH:23]2)[CH2:24][CH2:25][NH:26][C:27]4=[O:28])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 684643314-(1-Oxo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indol-8-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 684610838-(Piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

Sources & evidence

ORD record
ord-61f0d26dd4474d709dce148ad31a1bfc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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