3-Pentanamine → HCID 16038304, compound

HRID 1806245Notes

Reaction equation

HRID 1806245 reaction equation
[CH2:1]([S:3]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[C:16]([C:29]([NH2:31])=[O:30])[CH:17]=[C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]=O)[CH:22]=4)[CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])=[O:4])[CH3:2].[CH3:32][CH2:33][CH:34]([NH2:37])[CH2:35][CH3:36].[BH4-].[Na+]>>[CH2:33]([CH:34]([NH:37][CH2:27][C:23]1[CH:22]=[C:21]([C:18]2[CH:19]=[C:20]3[C:15](=[C:16]([C:29]([NH2:31])=[O:30])[CH:17]=2)[NH:14][CH:13]=[C:12]3[CH:9]2[CH2:8][CH2:7][N:6]([S:3]([CH2:1][CH3:2])(=[O:4])=[O:5])[CH2:11][CH2:10]2)[CH:26]=[CH:25][CH:24]=1)[CH2:35][CH3:36])[CH3:32]

Participants

4

Reactant 3

HCID 120193-PentanamineHCID 4311764Sodium borohydrideHCID 577328043-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-formylphenyl)-1H-indole-7-carboxamide

Product 1

HCID 16038304HCID 16038304, compoundYield 80.5%

Procedure

Following the general procedure of example 1, 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-formylphenyl)-1H-indole-7-carboxamide (20 mg, 0.045 mmol), 3-pentanamine (32 uL, 0.27 mmol) and NaBH4 (10 mg, 0.27 mmol) were reacted to give the title compound (18.5 mg, 80%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-53651ca18d284f64a298dcda8f71f569
Source dataset
uspto-grants-2013_01
Patent number
US08354406B2

Reaction notes

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