HCID 28305800, compound → 5-(5-{[(cyanomethyl)(methyl)amino]methyl}-3-thienyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	HCID 28305800	HCID 28305800	—
Reactant	5-(5-{[[(3,5-dimethyl-1H-pyrazol-4-yl)methyl](methyl)amino]methyl}-3-thienyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide	HCID 57732723	—
Product	5-(5-{[(cyanomethyl)(methyl)amino]methyl}-3-thienyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide	HCID 57732681	12.7%

Reaction Steps

The title compound was prepared according to the general procedure of 5-(5-{[[(3,5-dimethyl-1H-pyrazol-4-yl)methyl](methyl)amino]methyl}-3-thienyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide, substituting (methylamino)acetonitrile (320 μmol) for 1-(3,5-dimethyl-1H-pyrazol-4-yl)-N-methylmethanamine to afford 6.36 mg of the title compound (12.7%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354406B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-fb1e8b451f58413bba39455ba8ec2dc5
Source note	uspto-grants-2013_01