3-Methylbutanal → HCID 178446418, compound

HRID 1806715Notes

Reaction equation

HRID 1806715 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH:10](=O)[CH2:11][CH:12]([CH3:14])[CH3:13]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:10]/[CH2:11][CH:12]([CH3:14])[CH3:13])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 115523-MethylbutanalHCID 151417Glycine tert-butyl ester

Product 1

HCID 178446418HCID 178446418, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.65 g, 5 mmol) was reacted with isovaleraldehyde (Alfa) (0.43 g, 5 mmol) in CH2Cl2 at room temperature for 18 h to give [3-methyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (0.98 g, 98%).

Sources & evidence

ORD record
ord-61d360f4058548b6838b8c48fc986e4b
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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