3-Chlorobenzaldehyde → HCID 178451237, compound

HRID 1806719Notes

Reaction equation

HRID 1806719 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[Cl:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH:14]=O>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:14]/[C:13]1[CH:16]=[CH:17][CH:18]=[C:11]([Cl:10])[CH:12]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 114773-ChlorobenzaldehydeHCID 151417Glycine tert-butyl ester

Product 1

HCID 178451237HCID 178451237, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1a, glycine tert-butyl ester (1.31 g, 10 mmol) was reacted with 3-chlorobenzaldehyde (Aldrich) (1.4 g, 10 mmol) in CH2Cl2 at room temperature for 18 h to give {[1-(3-chloro-phenyl)-meth-(E)-ylidene]-amino}-acetic acid tert-butyl ester as a pale yellow oil (2.4 g, 95%).

Sources & evidence

ORD record
ord-3a1a1b9329a54784af2826eccd142208
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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