Pivalaldehyde → HCID 178446417, compound

HRID 1806762Notes

Reaction equation

HRID 1806762 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][C:11]([CH3:15])([CH3:14])[CH:12]=O>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:10]/[C:11]([CH3:15])([CH3:14])[CH3:12])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 12417PivalaldehydeHCID 151417Glycine tert-butyl ester

Product 1

HCID 178446417HCID 178446417, compoundYield 100.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.65 g, 5 mmol) was reacted with trimethylacetaldehyde (Aldrich) (0.42 g, 5 mmol) in CH2Cl2 at room temperature for 20 h to give [2,2-dimethyl-prop-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (1.0 g, 100%).

Sources & evidence

ORD record
ord-b8edee8a460a4e099e184054d86c4937
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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