反应详情

温度

80 °C

Step A A mixture of 3-chloro-4-(trifluoromethyl)benzyl alcohol (Synquest) (4.77 g, 23 mmol) and activated MnO2 (19.5 g, 230 mmol) in 1,2-dichlorethane (80 mL) was heated and stirred at 80° C. for 3 h. The mixture was cooled to room temperature and filtered through a short pad of celite. The celite was washed with dichloromethane, and ethyl acetate. The filtrates were combined, concentrated, dried under reduced pressure to give 3-chloro-4-(trifluoromethyl)benzaldehyde as a light yellow oil (2.8 g, 60%).

1. temperaturewas heated
2. temperatureThe mixture was cooled to room temperature
3. filtrationfiltered through a short pad of celite
4. washThe celite was washed with dichloromethane, and ethyl acetate
5. concentrationconcentrated
6. customdried under reduced pressure