反应详情

Step C To a solution of 3,3,4-trimethyl-pentan-1-ol (5.4 g, 41 mmol) in dichloromethane (100 mL) was added Dess-Martin periodinane (22 g 52 mmol) The reaction mixture was stirred at room temperature for 3 h. Aqueous Na2SO3 solution was added to quench the reaction. The organic layers were separated, washed with saturated NaHCO3, brine, dried over MgSO4, and concentrated. The residue was purified by chromatography (EtOAc:hexanes=1:30) to give 3,3,4-trimethyl-pentanal as a colorless oil (Yield: 1.1 g, 21%).

1. customto quench
2. customthe reaction
3. customThe organic layers were separated
4. washwashed with saturated NaHCO3, brine
5. dry with materialdried over MgSO4
6. concentrationconcentrated
7. customThe residue was purified by chromatography (EtOAc:hexanes=1:30)