Glycine tert-butyl ester → HCID 178451250, compound

HRID 1806895Notes

Reaction equation

HRID 1806895 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH:10]1([C:13]([CH3:18])([CH3:17])[CH2:14][CH:15]=O)[CH2:12][CH2:11]1>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:15]/[CH2:14][C:13]([CH:10]1[CH2:12][CH2:11]1)([CH3:18])[CH3:17])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 866403723-Cyclopropyl-3-methylbutanal

Product 1

HCID 178451250HCID 178451250, compoundYield 75.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step E In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.65 g, 5 mmol) was reacted with 3-cyclopropyl-3-methyl-butyraldehyde (0.68 g, 5.3 mmol) in CH2Cl2 at room temperature for 5 h to give [3-cyclopropyl-3-methyl-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (0.9 g, 75%).

Sources & evidence

ORD record
ord-9da494f0bd394f649ac9e42c88b302a0
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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