Glycine tert-butyl ester → HCID 178451249, compound

HRID 1806905Notes

Reaction equation

HRID 1806905 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[O:10]1[CH2:15][CH2:14][CH:13]([CH2:16][CH:17]=O)[CH2:12][CH2:11]1>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:17]/[CH2:16][CH:13]1[CH2:14][CH2:15][O:10][CH2:11][CH2:12]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 177509432-(Oxan-4-yl)acetaldehyde

Product 1

HCID 178451249HCID 178451249, compoundYield 35.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.65 g, 5 mmol) was reacted with (tetrahydro-pyran-4-yl)-acetaldehyde (Pharmacore) (0.64 g, 5 mmol) in CH2Cl2 at room temperature for 5 h to give [2-(tetrahydro-pyran-4-yl)-eth-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (0.43 g, 33%).

Sources & evidence

ORD record
ord-bd884d940e4b4e6cb0779ba333429a50
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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