Glycine tert-butyl ester → HCID 178451254, compound

HRID 1806918Notes

Reaction equation

HRID 1806918 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH2:10]([O:17][C:18](=[O:25])[C:19]([CH3:24])([CH3:23])[CH2:20][CH:21]=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)Cl>[CH2:10]([O:17][C:18](=[O:25])[C:19]([CH3:24])([CH3:23])[CH2:20]/[CH:21]=[N:8]/[CH2:7][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:9])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 856568462,2-Dimethyl-4-oxo-butyric acid benzyl ester

Product 1

HCID 178451254HCID 178451254, compoundYield 93.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step D In a manner similar to the method described in Example 1a, glycine tert-butyl ester (1.72 g, 13.2 mmol) was reacted with 2,2-dimethyl-4-oxo-butyric acid benzyl ester (4.1 g, 132 mmol) in CH2Cl2 at room temperature for 18 h to give 4-[(E)-tert-butoxycarbonylmethylimino]-2,2-dimethyl-butyric acid benzyl ester as a colorless oil (4.1 g, 93%).

Sources & evidence

ORD record
ord-8bcdc774b7c84b5cad02a21b0e7eed80
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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