反应详情

温度

0 °C

Step D To a solution of 3,3-diethyl-pentanoic acid methyl ester (1.9 g, 11 mmol) in anhydrous tetrahydrofuran (50 mL) at 0° C. was added a tetrahydrofuran solution (2 M) of LiAlH4 (9 mL, 18 mmol) under nitrogen. The reaction mixture was stirred at 0° C. for 1 h, then poured into a ice-water. The mixture was extracted with ethyl acetate. The organic layer were separated, washed with water, aqueous HCl solution, brine, dried over MgSO4, and concentrated to give 3,3-diethyl-pentan-1-ol as a yellow oil (1.4 g, 90%).

1. extractionThe mixture was extracted with ethyl acetate
2. customThe organic layer were separated
3. washwashed with water, aqueous HCl solution, brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated