Glycine tert-butyl ester → HCID 178424942, compound

HRID 1807024Notes

Reaction equation

HRID 1807024 reaction equation
[C:1]([O:5][C:6](=[O:9])[CH2:7][NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH3:10][C:11]([C:16]1[O:17][C:18]([CH3:21])=[CH:19][CH:20]=1)([CH3:15])[CH2:12][CH:13]=O>C(Cl)Cl>[C:1]([O:5][C:6](=[O:9])[CH2:7]/[N:8]=[CH:13]/[CH2:12][C:11]([CH3:15])([C:16]1[O:17][C:18]([CH3:21])=[CH:19][CH:20]=1)[CH3:10])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 866404373-Methyl-3-(5-methyl-furan-2-yl)-butyraldehyde

Product 1

HCID 178424942HCID 178424942, compoundYield 101.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Step F In a manner similar to the method described in Example 1a, glycine tert-butyl ester (0.79 g, 6 mmol) was reacted with 3-methyl-3-(5-methyl-furan-2-yl)-butyraldehyde 1 g, 6 mmol) in CH2Cl2 at room temperature for 5 h to give [3-methyl-3-(5-methyl-furan-2-yl)-but-(E)-ylideneamino]-acetic acid tert-butyl ester as a colorless oil (1.7 g, 100%).

Sources & evidence

ORD record
ord-b6bc9f15be8f4373818081574d10629d
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

Loading…