Dichloromethane → HCID 178501597, compound

HRID 1807029Notes

Reaction equation

HRID 1807029 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:7])[CH2:5][NH2:6].[CH3:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](C)(C)[CH2:17][CH:18]=O)=[CH:12][CH:11]=1.[CH2:22](N(CC)CC)[CH3:23].[CH2:29](Cl)Cl>>[CH3:2][O:3][C:4](=[O:7])[CH2:5]/[N:6]=[CH:22]/[CH2:23][C:17]([CH3:18])([CH3:29])[CH2:16][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH3:8])=[CH:15][CH:14]=1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 122755Glycine methyl ester hydrochlorideHCID 23504351HCID 23504351, compound

Product 1

HCID 178501597HCID 178501597, compoundYield 97%

Procedure

Step C In a manner similar to the method described in Example 1a, glycine methyl ester hydrochloride (1.25 g, 10 mmol) was reacted with 3-(4-methoxy-phenyl)-3-methyl-butyraldehyde (2.1 g, 10 mmol and triethylamine (2.2 g, 20 mmol) in CH2Cl2 at room temperature for 5 h to give [4-(4-methoxy-phenyl)-3,3-dimethyl-but-(E)-ylideneamino]-acetic acid methyl ester as a colorless oil (2.7 g, 97%).

Sources & evidence

ORD record
ord-417b6c01ef0e4d19a4d2e0168ade98cb
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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