反应详情

(S)-2-[(2,2,2-Trifluoro-ethanoylamino)-methyl]-piperidine-1-carboxylic acid tert butyl ester (18.2 g) was dissolved in methanol (500 ml) and treated with potassium carbonate (16.1 g). After stirring for 16 h solvent was removed at reduced pressure and the residue partitioned between dichloromethane/water. The organic phase was separated, washed with brine, dried and solvent removed at reduced pressure. the residue was column chromatographed (silica gel, 0-10% (9:1 methanol/ammonia) in dichloromethane eluant) to give the title compound (8.82 g) of description 1.

1. customwas removed at reduced pressure
2. customthe residue partitioned between dichloromethane/water
3. customThe organic phase was separated
4. washwashed with brine
5. customdried
6. customsolvent removed at reduced pressure
7. customchromatographed (silica gel, 0-10% (9:1 methanol/ammonia) in dichloromethane eluant)