反应详情

A solution of 2-ethoxy-4-nitrobenzoic acid (2.035 g, 9.45 mmol, Aldrich) in methanol (40 ml) was treated with p-toluenesulfonic acid monohydrate (583.3 mg, 3.07 mmol) and heated at reflux under argon for 17 hrs. The solvent was removed and the residue was dissolved in ethyl acetate, washed with saturated Na2CO3, water and saturated NaCl and dried over Na2SO4, filtered and concentrated to give methyl 2-ethoxy-4-nitrobenzoate (2.15 g, 101%) as a yellow solid.

1. temperatureheated
2. temperatureat reflux under argon for 17 hrs
3. customThe solvent was removed
4. dissolutionthe residue was dissolved in ethyl acetate
5. washwashed with saturated Na2CO3, water and saturated NaCl
6. dry with materialdried over Na2SO4
7. filtrationfiltered
8. concentrationconcentrated