Triethylamine → HCID 131730168, compound

HRID 1807388Notes

Reaction equation

HRID 1807388 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C@@H:9]1[CH2:11][C@H:10]1[CH:12]([NH:14][O:15][CH3:16])[CH3:13].C(N(CC)CC)C.[F:24][CH:25]([F:35])[C:26]1[C:30]([C:31](Cl)=[O:32])=[CH:29][N:28]([CH3:34])[N:27]=1>ClCCl.O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C@@H:9]1[CH2:11][C@H:10]1[CH:12]([N:14]([O:15][CH3:16])[C:31]([C:30]1[C:26]([CH:25]([F:35])[F:24])=[N:27][N:28]([CH3:34])[CH:29]=1)=[O:32])[CH3:13]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 153401103-(Difluoromethyl)-1-methyl-1 H-pyrazole-4-carbonyl chlorideHCID 86669069HCID 86669069, compound

Product 1

HCID 131730168HCID 131730168, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of trans N-{1-[2-(2-Chloro-6-fluoro-phenyl)-cyclopropyl]-ethyl}-O-methyl-hydroxylamine (0.80 g; 3.3 mmol) prepared as described in example P14 and triethylamine (0.60 ml; 4.3 mmol) in dichloromethane (10 ml) at ambient temperature was added dropwise 3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonyl chloride (0.64 g; 3.3 mmol). The reaction mixture was stirred for 16 hours at ambient temperature then poured in water (60 ml) and extracted with dichloromethane (3×25 ml). Combined organic layers were washed with water (10 ml), brine and dried over anhydrous sodium sulphate. The solvent was removed in vacuo and the residue was purified by flash chromatography over silica gel (elution gradient: cyclohexane/ethyl acetate 99:1 to 1:99) to afford 1.30 g (100% of theory) of trans 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {1-[2-(2-chloro-6-fluoro-phenyl)-cyclopropyl]-ethyl}-methoxy-amide as a clear viscous oil.

Workup

  1. extractionextracted with dichloromethane (3×25 ml)
  2. washCombined organic layers were washed with water (10 ml), brine
  3. dry with materialdried over anhydrous sodium sulphate
  4. customThe solvent was removed in vacuo
  5. customthe residue was purified by flash chromatography over silica gel (elution gradient: cyclohexane/ethyl acetate 99:1 to 1:99)

Sources & evidence

ORD record
ord-e44febccd02245e7ae3a760b4d057c9e
Source dataset
uspto-grants-2013_01
Patent number
US08357635B2

Reaction notes

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