Ethanolamine → HCID 49800449, compound

HRID 1807499Notes

Reaction equation

HRID 1807499 reaction equation
CO[C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:14][O:15][C:16]=2[CH3:17])=[N:6][CH:5]=1.[CH2:23]([CH2:25][NH2:26])[OH:24]>>[CH2:18]([C:13]1[C:12]([CH2:11][O:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([NH:26][CH2:25][CH2:23][OH:24])=[O:22])=[CH:5][N:6]=2)=[C:16]([CH3:17])[O:15][N:14]=1)[CH2:19][CH2:20][CH3:21]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 665991586-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester

Product 1

HCID 49800449HCID 49800449, compoundYield 60%

Procedure

As described for example 9, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (500 mg, 1.4 mmol) was converted, using ethanolamine instead of rac-2-amino-1-propanol, to the title compound (280 mg, 60%) which was obtained as a colourless oil after purification by chromatography (silica, 0 to 5% methanol in dichloromethane). MS: m/e=334.3 [M+H]+.

Sources & evidence

ORD record
ord-cb09d1b24e1d4d9d88aa58755a83a8d5
Source dataset
uspto-grants-2013_01
Patent number
US08357703B2

Reaction notes

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