HCID 66643649, compound → HCID 49801608, compound

HRID 1807539Notes

Reaction equation

HRID 1807539 reaction equation
CO[C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[C:13]([N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)=[N:14][O:15][C:16]=2[CH3:17])=[N:6][CH:5]=1.COC(=O)C1C=CC(OC[C:35]2[C:36]([CH2:41]CC(F)(F)F)=[N:37]OC=2C)=NC=1>>[CH:36]([NH:37][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[C:13]([N:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)=[N:14][O:15][C:16]=2[CH3:17])=[N:6][CH:5]=1)([CH3:41])[CH3:35]

Participants

3

Reactant 2

HCID 66643649HCID 66643649, compoundHCID 66646028HCID 66646028, compound

Product 1

HCID 49801608HCID 49801608, compoundYield 55%

Procedure

As described for example 1e, 6-(5-methyl-3-pyrrolidin-1-yl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (100 mg, 0.28 mmol), instead of 6-[5-methyl-3-(3,3,3-trifluoro-propyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester, was converted, to the title compound (30 mg, 55%) which was obtained as a white solid after purification by chromatography (silica, 30 to 60% ethyl acetate in heptane). MS: m/e=345.2 [M+H]+.

Sources & evidence

ORD record
ord-4a9f6d4f03f3479e8a691399f42611c1
Source dataset
uspto-grants-2013_01
Patent number
US08357703B2

Reaction notes

Loading…