HCID 66643649, compound → HCID 49801608, compound

Participants

Reaction Steps

As described for example 1e, 6-(5-methyl-3-pyrrolidin-1-yl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (100 mg, 0.28 mmol), instead of 6-[5-methyl-3-(3,3,3-trifluoro-propyl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester, was converted, to the title compound (30 mg, 55%) which was obtained as a white solid after purification by chromatography (silica, 30 to 60% ethyl acetate in heptane). MS: m/e=345.2 [M+H]+.

Provenance & Evidence