反应详情

温度

90 °C

Phthalimide potassium was suspended in DMF (35 mL) and the reaction mixture heated to 90° C. A solution of 3-butyl-4-chloromethyl-5-methyl-isoxazole (970 mg, 5.2 mmol) in DMF (25 mL) was added. After 45 min the reaction mixture was cooled, evaporated and the residue obtained was diluted with water then extracted with ether. The combined organic extracts were dried, filtered and concentrated then purified by chromatography (silica, 0 to 50% ethyl acetate in heptane) to give the title compound (1.21 g, 78%) as an off white solid that was used directly in the next step.

1. temperatureAfter 45 min the reaction mixture was cooled
2. customevaporated
3. customthe residue obtained
4. extractionthen extracted with ether
5. customThe combined organic extracts were dried
6. filtrationfiltered
7. concentrationconcentrated
8. customthen purified by chromatography (silica, 0 to 50% ethyl acetate in heptane)