反应详情

温度

55 °C

2-(3-Butyl-5-methyl-isoxazol-4-ylmethyl)-isoindole-1,3-dione (1.20 g, 4.0 mmol) was dissolved in MeOH (20 mL) then hydrazine hydrate (1.51 g, 30.1 mmol) was added and the reaction mixture heated at 55° C. After 2 h the reaction mixture was cooled and filtered. The filtrate was evaporated then purified by chromatography (silica, 2 to 10% methanol in dichloromethane) to give the title compound (550 mg, 81%) as a yellow liquid. MS: m/e=348.5 [M+H]+.

1. temperatureAfter 2 h the reaction mixture was cooled
2. filtrationfiltered
3. customThe filtrate was evaporated
4. customthen purified by chromatography (silica, 2 to 10% methanol in dichloromethane)