反应详情

温度

160 °C

C-(3-Butyl-5-methyl-isoxazol-4-yl)-methylamine (320 mg, 1.90 mmol) was dissolved in DMSO (3 mL), methyl 6-chloronicotinate (326 mg, 1.90 mmol) and N,N-diisopropylethylamine (492 mg, 3.80 mmol) added, and the reaction mixture heated under microwave irradiation at 160° C. for 1 h. The reaction mixture was poured onto ice-water and extracted with ethyl acetate. The combined organic extracts were dried, filtered and concentrated then purified by chromatography (silica, 0 to 50% ethyl acetate in heptane) to give the title compound (280 mg, 49%) as a white solid. MS: m/e=348.5 [M+H]+.

1. additionThe reaction mixture was poured onto ice-water
2. extractionextracted with ethyl acetate
3. customThe combined organic extracts were dried
4. filtrationfiltered
5. concentrationconcentrated
6. customthen purified by chromatography (silica, 0 to 50% ethyl acetate in heptane)