Ammonia → HCID 57420321, compound

HRID 1807654Notes

Reaction equation

HRID 1807654 reaction equation
[CH3:1][O:2][CH2:3][C@@:4]12[CH2:16][CH2:15][CH2:14][N:5]1[C@@H](C(Cl)(Cl)Cl)[O:7][C:8]2=O.[NH3:17]>CO>[CH3:1][O:2][CH2:3][C@@:4]1([C:8]([NH2:17])=[O:7])[CH2:16][CH2:15][CH2:14][NH:5]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58092771HCID 58092771, compound

Product 1

HCID 57420321HCID 57420321, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (3R,7aR)-7a-methoxymethyl-3-trichloromethyl-tetrahydro-pyrrolo[1,2-c]oxazol-1-one (Stage G.1, 0.6 g) and 7 M ammonia in MeOH (6 mL) was stood at rt for 2 days in a sealed vessel. The RM was then evaporated to give the title compound as a pale yellow oil which was used without further purification.

Workup

  1. customThe RM was then evaporated

Sources & evidence

ORD record
ord-bb21e97be27d41ec8a2dcf7d3b649778
Source dataset
uspto-grants-2013_01
Patent number
US08357707B2

Reaction notes

Loading…